在exon 1的上游插入了一个loxP位点,接着在内含子1中包含了一个FRT位点的诺卡因抗性基因座,旁边跟着另一个loxP位点。随后通过flp介导的重组移除了诺卡因基因座,产生了一个条件性可操作的等位基因,exon 1区域去除了(来源:J:270001)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C3H x C57BL/6)F1
Targeted
插入
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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