ENU-induced T to C transition at base pair 28,781,907 (v38) on chromosome 10, or base pair 113,581 in the GenBank genomic region NC_000076 encoding Themis. The mutation corresponds to residue 1,229 in the mRNA sequence NM_178666 within exon 4 of 6 total exons. The mutation results in an isoleucine to threonine substitution at position 310 (I310T) in the Themis protein. (J:274716)