在exon 10的上游插入了一个frt-flanked neomycin筛选 cassette,然后在exons 1012的周围插入了loxP位点。通过FLP介导的重组移除了neomycin筛选 cassette,留下了loxP位点。随后的Cre介导重组导致了exon 10-12区域的loxP标记区域被删除。(来源:J:259650)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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