Unc93b1^em1Btlr

The CRISPR/Cas9 system and sgRNA 5'-AGGAAGTCCCAACCAGCTGC-3' was used to generate the mice. The CRISPR/Cas9 system generated a 109-base pair deletion at c.138_28del (NM_019449.2). The mutation is predicted to cause a frame-shifted protein product beginning after amino acid 7 of the protein and premature termination after the inclusion of 63 aberrant amino acids. (J:274652)