在exon 5上游插入了一个带有5' loxP位点的FRT引导的诺姆霉素抗性基因座,接着在exon 5下游也插入了一个loxP位点。通过Cre介导的重组,这个选择性基因座和exon 5被去除了。免疫印迹实验确认了在小鼠胚胎成纤维细胞中没有检测到蛋白质。(来源:J:269823)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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