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中文
CRISPR/Cas9通过合成寡脱氧核苷酸进行同源重组，导致Trem2基因第3外显子中的一个C转换为T，产生了H157Y的氨基酸替换。此外，两个无义突变在protospacer/PAM区域内产生了ApaLI的限制性酶切位点，用于基因分型。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
