Casp8^M2Btlr

ENU-induced T to A transversion at base pair 58,833,698 (GRCm38) on chromosome 1, or base pair 38,471 in the GenBank genomic region NC_000067 encoding caspase-8. The mutation corresponds to residue 1,125 in the mRNA sequence NM_009812, within 7 of 9 exons. The mutation results in a histidine to glutamine substitution at position 244 (H244Q) in the caspase-8 protein (isoform 1). (J:272851)