CRISPR/Cas9技术删除了exon 11,导致了框架移位、早终止密码子和无义等位基因。 Western blot结果显示肾脏中没有检测到蛋白质(来源:J:272435)
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CRISPR/Cas9 technology deleted exon 11 resulting in a frameshift and premature termination codon and a null allele. Western blot analysis confirmed absence of protein in kidneys. (J:272435)