Pcdhg^em35Rwb

This allele was generated through shotgun CRISPR/Cas9 editing using pooled sgRNAs that targeted each variable exon of the Pcdhg cluster and this allele was found to have small frameshift mutations disrupting the variable exons A12 and C5, a 9bp in-frame deletion in variable exon C4, which deletes amino acids 27-29 in the signal peptide, and a large 94 kb deletion spanning from variable exon A1 into A11, which leaves un-mutated only variable exons B8 and C3. (J:285314)