这个等位基因是通过shotgun CRISPR/Cas9编辑通过设计针对Pcdhg基因簇每个可变外显子的pool sgRNAs产生的,且这个特定的等位基因在可变外显子B8仅发现了一个框移的插入突变。 (Source: The allele was generated through CRISPR/Cas9 with pooled sgRNAs targeting Pcdhg variable exons, and it had a frameshifting indel in exon B8.)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因内删除
不确定
--
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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