这个等位基因是通过shotgun CRISPR/Cas9编辑通过设计针对Pcdhg基因簇所有可变exon的pool sgRNAs产生的,检测到它存在破坏性frameshift插入和变异exonA12的框架错乱,以及包含变异exonsB1到B8的结构重组,剩下6个exons保持完整。(来源:J:285314)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因内删除
不确定
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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