靶向载体设计为在基因的1号外显子上游插入一个loxP位点,然后是带有FRT标签的诺卡因选择座,接着是1号外显子下游的另一个loxP位点。通过Flp介导的重组,FRT标记的诺卡因座被移除,使得1号外显子成为可调节的。(来源:J:288162)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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