4930503L19Rik^{rs241863237-del}

The C57BR/cdJ, C57L/J, 129S1/SvImJ, AKR/J, BALB/cJ, C3H/HeJ, CAST/EiJ, CBA/J, PL/J, DBA/2J, SM/J, LP/J, ST/bJ and WSB/EiJ strains carry this allele. The molecular difference with other strains is the deletion of nine base pairs (GGCGCTGTC) in the coding region of exon 3 of the gene in the Par2 (pulmonary adenoma resistance 2) region. This deletion removes three codons, GAC-AGC-GCC coding for Asp-Ser-Ala (amino-acids 32-34 in UniProt Q8CB14), that confer sensitivity to urethane-induced pulmonary adenomas. This allele co-occurs with the 4930503L19Rikrs30066196-C, 4930503L19Rikrs216509331-T, 4930503L19Rikrs29775155-A, 4930503L19Rikrs30245983-G, and 4930503L19Rikrs222904565-ins alleles to confer resistance. Through epistatic interaction with the Lrmprs13459098-C sensitive and Lrmprs13459098-T resistant alleles in the pulmonary adenoma susceptibility 1 (Pas1) region these Par2 alleles modulate the sensitivity or resistance of the two Pas1 alleles. (J:150946)