4930503L19Rik^rs30066196-C

This C variant of the SNP is found in exon 3 (the first coding exon) of the gene in the Par2 (pulmonary adenoma resistance 2) region in the C57BR/cdJ, AKR/J, C57L/J, C3H/HeJ, DBA/2J, SM/J, LP/J, CBA/J, PL/J, 129S1/SvImJ, ST/bJ, and BALB/c strains and creates an arginine codon (CGA) at position 13 (UniProt Q8CB14). It co-occurs with the 4930503L19Rikrs29775155-A, 4930503L19Rikrs216509331-T, 4930503L19Rikrs30245983-G, 4930503L19Rikrs222904565-ins, and 4930503L19Rikrs241863237-del alleles to confer resistance to urethane-induced pulmonary adenomas. Through epistatic interaction with the Lrmprs13459098-C sensitive and Lrmprs13459098-T resistant alleles in the pulmonary adenoma susceptibility 1 (Pas1) region these Par2 alleles modulate the sensitivity or resistance of the two Pas1 alleles. (J:150946)