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中文
CRISPR/Cas9基因编辑技术被用来改变来自Krastm4Tyj突变小鼠的胚胎干细胞。原始的Kras小鼠在基因的exon 2第二外显子有一个G12D点突变，并在 intron 1有一个由loxP序列标记的终止子。使用针对KrasG12D位点的引导RNA、单链DNA模板和Cas9核酸酶，目的是引入一个常见的胰腺导管腺癌相关变异，即p.G12R（c.34_36delGGTinsCGA）。(来源：J:299292)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
