Tg(tetO-Grin2a/Grin2b)#Dumas

This chimeric N-methyl-D-aspartate receptor (NMDAR) subunit transgene was created as follows: a tetracycline response elemet (TRE) was placed upstream of sequence coding for the extracellular N-terminus and transmembrane domains of the Grin2a peptide, fused to sequence coding for the intracellular C-terminal portion of the Grin2b peptide. When mice containing this transgene are crossed to mice expressing a tTA or rtTA transgene, expression of this allele can be switched off or on on demand through the application of tetracycline. (J:271402)