Brca1^em1Njo

CRISPR/Cas9 technology generated a 4 bp deletion (c.4080-4083) resulting in a frame shift mutation. This mutation results in a p.1361fs28X stop codon in the coiled-coil (CC) domain that blocks translation in the CC domain and is predicted to cause loss of the C-terminal region of the protein that includes the CC and BRCT domains. (J:271205)