Grin2b^tm2.1Nhk

Three mutations, a leucine to alanine at amino acid 1298, an arginine to asparagine at amino acid 1300, and a serine to aspartate at amino acid 1303 (L1298A/R1300N/S1303D), were introduced in the CTD2B sub-region, and a loxP-flanked neomycin phosphotransferase gene driven by a compound phosphoglycerate kinase (PGK) and EM7 promoter was inserted. The mutations abrogate CaMKII binding to Grin2b. Cre-mediated recombination removed the neo cassette. (J:271055)