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在胚胎干细胞中，通过插入一个由tamoxifen诱导的编码改进的Cre重组酶(iCre)，它被两个突变的雌激素受体位点(MeriCreMer)所 flank，这些位点位于Tie1基因的起始外显子。这种融合蛋白MeriCreMer在内源性Tie1启动子的调控下表达。随后，通过与FLP敲除小鼠杂交，去除了带有FRT标记的Neo cassette。(来源：J:250996)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
