在 intron 2 和 intron 5 处分别插入了 loxP 立场和 FRT 立场,随后插入了诺卡因抗性基因座。通过后续的 flp 介导重组,去除了 neo 酶座,留下了一个带有 3-5 号外显子被敲除的条件性准备好等位基因。(来源:J:269898)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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