α肌动蛋白重链启动子驱动了心脏特异性的Kcnj8突变型(由甘氨酸-苯丙氨酸-甘氨酸替换为三个Alanine的孔部区域)表达,该突变型带有C端增强型绿色荧光蛋白标记。RT-PCR和 Western blot实验确认了转基因在心脏中的特异性表达。多条克隆产生了,但仅有一条被进一步研究。(来源:J:116284)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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