编码区都被lacZ基因和含loxP位点的抗氨苄青霉素抗性基因座替换。随后通过Cre介导的重组移除了neo cassette。这导致了产生出的纯合突变小鼠在肝脏中不表达编码的mRNA和蛋白质。(来源:200103)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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