一只仓鼠的PrP启动子驱动了人类SNCA(A30P)突变形式的表达。产生了两条转基因小鼠品系,Tg5093和Tg5102。高表达的品系(Tg5093)显示了大脑中A30P型α-synuclein有15倍的转基因水平,并伴随年龄相关的运动障碍,这些特征被详细研究了(来源:J:102796)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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1
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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