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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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基因编辑小鼠
Ghrl
em3Jmz
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基础信息
表型特征
文献报道
在Exon 2通过CRISPR-cas9插入了3个连续的内含子终止密码子和额外的非同源框终止密码子。GKO1和GKO3两个突变体被培育成了品系。免疫组化分析证实了纯合小鼠胃组织中表达缺失。(来源:J:268617)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
6273205
C57BL/6N
Endonuclease-mediated
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1
1
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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