一段大约2.5kb的区域,包括1号外显子和上游启动子,被替换为FRT位点、puro cassette、Lox5171位点和另一个FRT位点。通过Flp介导的重组,移除了插入物,剩下单一的FRT位点。靶向操作是在携带Bcl2a1atm1Tac(J:258915)的ES细胞上进行的。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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