ENU-induced T to C transition at base pair 3,161,770 (v38) on chromosome 8, or base pair 117,880 in the GenBank genomic region NC_000074 encoding Insr. The mutation corresponds to residue 3,739 in the mRNA sequence NM_010568 within exon 17 of 21 total exons. The mutation results in a serine (S) to proline (P) substitution at position 1,084 (S1084P) in the InsR protein. (J:267534)