在ATG起始点大约200bp上游插入了loxP位点,通过同源重组,一段FRT标记的neo cassette和一个loxP位点被插入到exon1的下游。随后,Flp介导的重组移除了neo cassette,使得exon1成为可删除的(来源:J:266702)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count