这种由TALEN诱发的突变发生在携带retinal degeneration 8(rd8)基因这一特定等位的菌株中,它在exon 9中有5个不连续的碱基对缺失,原始rd8突变的第3481位核苷酸,随后是3486到3489位,这会导致框架移位,并引入11个全新的氨基酸,然后提前终止(来源:J:265859)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Crb1rd8 Jak3m1J/BocJ
Endonuclease-mediated
基因内删除
不确定
1
12
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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