使用(Rr94tm3.2Litt)胚胎,通过CRISPR/cas9技术,用到了针对AAGCCAGGCTACTTGTTTAC和AGCCAATTCCCAGCGTGCGT的gRNAs,实现了Cd4基因内含子1中的"成熟"增强子E4m的消除。这个E4m是一个位于chr6:124861957-124862580(GRCm39)的新型顺式调控元件。来源:(J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Endonuclease-mediated
基因内删除
--
1
2
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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