基于TALEN的基因组编辑被用来引入8个核苷酸变异,目的是替换β-actin基因的D2-4、V10区域,转译为γ-actin的E2-4、I10,以及打断TALEN对编辑位点的再结合。这些小鼠缺失β-actin蛋白。(来源:J:265862)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Endonuclease-mediated
核苷酸替换
--
1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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