受精卵的核被注入了bWap-SEAP这种细菌人工染色体(BAC),它包含了24kb的鼠乳清酸蛋白基因,驱动了人胎盘碱性磷酸酶(无膜锚定区域的SEAP,ClonTech)分泌型的表达。这种基因作为报告器的启动子/增强子。b6727品系的小鼠携带单个转基因拷贝。这些小鼠的乳腺中SEAP的表达量在每毫升乳汁中达到4.3-5.1ug;在肾、肝、肌肉、脑和肺等其他组织中未检测到异位表达。(来源:J:82809)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
HsdWin:NMRI
Not Applicable
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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