这个转基因是通过将含有C3H正常着色小鼠种系中酪氨酸酶基因及其5'上游DNA(通过调控区LCR,位于基因约12kb上游)的酵母人工染色体(YAC,代号YRT3)微注射到受精的雌鼠卵子中产生的。它在缺失了部分5'序列的情况下,成功证明了其表达,因为它能完全恢复白化(Tyrc/Tyrc)小鼠的色素表型。这个转基因品系尚未公开发布。(来源:J:223068)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x CBA)F2
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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