将人的cDNA放置在最小的CMV启动子后面,并结合了五个四环素响应元件。构建物通过胚胎的核内微注射技术导入FVB/NCr胚胎中。这种外源基因只有当携带有这种等位基因的鼠与携带tTA或rtTA等位基因的鼠杂交时,才会以四环素/多西环素可调控的方式表达。(来源:J:265381)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/NCr
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插入
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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