Mecp2^tm8.1Bird

A point mutation was created in exon 4 (c.674 C>G; coordinates refer to human e2 isoform) to change codon 225 from proline to arginine (p.P225R or p.Pro225Arg). This mutation is associated with human Rett syndrome. The loxP site flanked neomycin resistance gene and STOP cassette that was inserted into intron 2 was removed through subsequent cre-mediated recombination. (J:265095)