Ednrb^s-3Btlr

ENU-induced T to C transition at base pair 103,821,714 (v38) on chromosome 14, or base pair 22,763 in the GenBank genomic region NC_000080 encoding Ednrb. The mutation corresponds to residue 1,286 in the mRNA sequence NM_001136061.2 within exon 5 of 8 total exons. The mutation results in a phenylalanine to serine substitution at amino acid 292 (F292S) in both endothelin receptor type B (ETBR) isoforms. (J:264716)