Clock^m1Btlr

ENU-induced C to T transition at base pair 76,229,554 (v38) on chromosome 5, or base pair 75,447 in the GenBank genomic region NC_000071 encoding Clock. The mutation corresponds to residue 2,285 in the NM_007715 mRNA sequence in exon 21 of 23 total exons, residue 2,242 in the NM_001289826 mRNA sequence in exon 21 of 23 total exons, and residue 2,101 in the NM_001305222 mRNA sequence in exon 21 of 23 total exons. The mutation results in substitution of glutamine 633 to a premature stop codon (Q633*) in the CLOCK protein. (J:264640)