这个小的组织相容性抗原,最初在C57BL/10ScSn和129/Rr之间发现,后来也在C57BL/6J和129P3/J间发现,是由第25位氨基酸的单一替换引起的,C57BL/6J来源的H46-a是Alanine,而129来源的H46-b是 Methionine。这种变化背后的两个核苷酸序列变异是G73A和C74T,它们各自的核心抗原肽在结合抗体时表现相似。H46-b的-core抗原肽序列是HMFVEAIPELQ。(来源:J:264442)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Not Applicable
核苷酸替换
半显性
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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