构建了一个靶向鸡卵白质Ovalbumin(去信号序列)和 Legionella pneumophila鞭毛C端166氨基酸序列融合,后面跟着一个带有IRES-GFP的转录停止子的loxP位点调控元件。这个构造产生了一个条件性可表达的等位基因,只有在Cre介导的停止子被删除后才会表达。鞭毛的表达会激活内源性NAIP/NLLRC4的炎症小体,而Ovalbumin则用于追踪适应性免疫反应(来源:J:260047)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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