RMCE通过替换Gt(ROSA)26Sortm1(CAG-flpe)Arte中的选择子 cassette,用一个5'去除了新氨苄青霉素抗性基因 cassette、鸡肌动蛋白基因(CAG)启动子、LoxP标记的强转录终止位点(LSL)、人类MYCN基因、插入序列(IRES)和荧光素酶基因(firefly luciferase)来实现。利用Cre介导的重组,可以消除MYCN基因等位基因上游的转录终止位点,以获得MYCN的表达。(来源:J:222527)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x 129S6/SvEvTac)F1
Targeted
插入
--
--
--
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部