CRISPR/Cas9介导的重组在exon 1产生了一个8个碱基的缺失(GGCCTGAG)。 Western blot分析证实了纯合小鼠中蛋白质表达的缺失(来源:J:265543, J:326577)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count