Exon 2被LoxP位点前后标记,通过同源重组,插入了一个FRT-介导的neo cassette在第一个LoxP位点上游。通过Flp介导的重组移除了选择性 cassette。随后,Cre介导的重组去除了Exon 2,导致了框架移位突变。(来源:J:264147)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入,基因内删除
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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