在内含子1中插入了以下元素:一个剪接接受器、CAG启动子、loxP位点、诺卡因抗性基因座、第二个loxP位点、ATTB1位点、RSpo1基因(exons 2-5)的cDNA序列、内含子序列、exon 6(包括3' UTR)的cDNA序列、第二个ATTB1位点以及poly(A)信号。这构建了一个条件性可诱导表达的等位基因,只有在Cre介导去除neo cassette后,插入基因才会被表达。(来源:J:259735)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
插入
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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