在 intron 4 中插入了带有 hygromycin 抗性基因座的敲除 cassette,同时在 intron 9 处额外插入了 loxP 突变位点。通过 Cre 基因的介导重组,去除了选择 cassette,使得 exons 5 到 9 成为可敲除区域。(来源:J:262823)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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