捐赠者通过体内同源重组技术,在小鼠染色体19号上构建了一个与人类9p24.1区域同源的0.9兆碱基缺失。这个删除涉及了Rln1、Plgrkt、Cd274、Pdcd1lg2、Ric1、Ermp1、Mlana、9930021J03Rik、Ranbp6、Il33、Trpd52l3、Uhrf2和Gldc等基因。简而言之,捐赠者通过靶向该区域两侧的位点插入loxP序列,通过Cre介导的重组,实现了序列的复制或删除。(来源:J:94077)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
重复
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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