Del(19Rln1-Gldc)1Uru

The donor constructed mice with a 0.9-Mb deletion on mouse chromosome 19 syntenic with the human 9p24.1 region by trans-allelic recombination in vivo. The deletion includes the genes Rln1, Plgrkt, Cd274, Pdcd1lg2, Ric1, Ermp1, Mlana, 9930021J03Rik, Ranbp6, Il33, Trpd52l3, Uhrf2, Gldc. Briefly, the donor inserted loxP sites into the mouse genome by targeting sites to flank the region to duplicate or delete. Mice were bred that carry the two loxP sites in trans and an Hprt-Cre transgene (RRID:IMSR_JAX:004302). (J:94077)