来自Shank3tm1.1Bux小鼠的ES细胞被重新定向,以在第22外显子下游插入第三个loxP位点。这种等位基因包含在第4外显子上游插入一个loxP位点,在第9外显子下游插入第二个loxP位点,以及在第22外显子下游插入第三个loxP位点。通过Cre介导的重组,去除了4-22号外显子。(引用文献:J:175320, J:270363)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
基因内删除
--
1
5
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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