CRISPR/cas9通过单链寡核苷酸,包含同源臂,用于在ROSA26基因座的内含子1中插入一个48bp的Bxb1 attP-GT靶位点,这种方法是通过同源修复(HDR)实现的(来源:J:322700)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
Endonuclease-mediated
插入
不确定
--
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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