RT-PCR和免疫组化分析显示,纯合子小鼠中mRNA表达显著减少,且蛋白表达缺失。然而,Myo6基因的外显子序列、剪接边界和启动子区域未检测到突变。在RSV小鼠和野生型小鼠中都发现了Myo6的一个替代剪接变异体,非重组区域位于D9Mit74到D9Nok18。(来源:J:261136)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6Slc
Spontaneous
未定义
隐性
1
7
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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