Flp-mediated excision of the parental Bscl2tm1a(EUCOMM)Hmgu allele resulted in the removal of lacZ reporter sequence and the neomycin selection cassette, leaving exon 5-7 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:260853)