这个靶向构建插入了a CAG启动子、一个由loxP标记的转录终止子和一个在第1535位由T替换为G的Slc39A14突变鼠,导致L438位氨基酸由亮氨酸替换为arginine。要表达这个突变蛋白,需要通过Cre介导的重组来去除终止子。来源:(J:261326)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
插入
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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